Active Grants and Projects

Developmental Center for Clinical and Translational Science in Chiropractic (DCRC I)

Funding source: NIH/NCCAM
Grant number: 1-U19-AT004663
Award amount: $3,537,049
Funding period: 6/2008 - 5/2014
Principal Investigator: Christine Goertz, DC, PhD

The long range goal is to understand the appropriate clinical role of spinal manipulation in our evolving healthcare system by developing models for the rigorous conduct of clinical and translational research involving manipulative techniques These projects are in collaboration with University of Iowa, Loyola University Stritch School of Medicine and Hines VA Hospital.

DCRC I: Project 1: Patient Response to Spinal Manipulation (PRiSM)

Co-leaders: Ting Xia, PhD and David Wilder, PhD
Co-investigators: Cynthia Long, PhD; James DeVocht, DC, PhD; Ram Gudavalli, PhD; Robert Vining, DC

DCRC I: Project 2: Conservative Treatment of Patients with Temporomandibular Disorders (TMD)

Co-leaders: James DeVocht, DC, PhD and Clark Stanford, DDS, PhD
Co-investigators: Cynthia Long, PhD; Maria Hondras, DC, MPH; Walter Schaeffer, DC

Publications
DeVocht JW, Goertz CM, Hondras MA, Long CR, Schaeffer W, Thomann L, Spector M, Stanford CM. A Pilot Study of a Chiropractic Intervention for Management of Chronic Myofascial Temporomandibular Disorder. JADA 2013;144(10):1154-1163.

DCRC I: Project 3: Cervical Distraction Sham Development: Translating from Basic to Clinical Studies (MCD)

Co-leaders: Ram Gudavalli, PhD and Avinash Patwardhan, PhD
Co-investigators: Cynthia Long, PhD; Charles Henderson, DC, PhD; Robert Havey, BS; Leonard Voronov, MD, PhD; Alexander Ghanayem, MD; Robert Vining, DC

Publications
Gudavalli MR, Potluri T, Carandang G, Havey R, Voronov L, Cox J, Rowell R, Kruse R, Joachim G, Patwardhan AG, Henderson CNR, Goertz C. Intradiscal Pressure Changes during Manual Cervical Distraction: A Cadaveric Study. Evid-Based Compl Alt 2013, Article ID 954134

DCRC I: Clinic and Data Core

Co-leaders: Cynthia Long, PhD; Robert Vining, DC

Assessment of Chiropractic Treatment for Low Back Pain, Military Readiness, and Smoking Cessation in Military Active Duty Personnel

Funding source: Department of Defense
Grant number: W81XWH-10-DHP-CCTA
Award amount: $5,214,001Funding period: 2/2011 - 1/2015Principal investigator: Ian D. Coulter, PhD, RAND CorporationCo-principal investigator: Christine Goertz, DC, PhDCo-investigators: Cynthia Long, PhD; James DeVocht, DC, PhD; Ram Gudavalli, PhD; Ting Xia, PhD; Robert Vining, DCProject Managers: Katherine Pohlman, DC, MS, CCRP; Bridget Kane, MS, CCRC

Defense Health Program Chiropractic Clinical Trial Award: The primary goal is to assess the effectiveness of chiropractic manipulative therapy for pain management and improved function in active duty service members with orthopedic injuries or disorders of the low back.

Expanding EBCP and Research across the Palmer College of Chiropractic

Funding source: NIH/NCCAM
Grant number: 2-R25-AT003580
Award amount: $1,634,963
Funding period: 9/2007 - 8/2016
Principal Investigator: Cynthia Long, PhD
Collaborators: Kevin Lyons, PhD; Mark Wilson, MD, MPH; Kristi Ferguson, PhD
Program Manager: Katie Hoyt, MOL

In collaboration with the University of Iowa and Thomas Jefferson University, this grant supports an on-going faculty development program toward enhancing the integration of evidence-based clinical practice (EBCP) and research content into the Doctor of Chiropractic curriculum at all three Palmer campuses.

Effect of Lumbar Hypo & Hypermobility on Sensory Response to Spinal Manipulation

Funding source: NIH/NCCAM
Grant number: 5-K01-AT005935
Award amount: $646,840
Funding period: 9/2010 – 8/2015
Principal Investigator: William Reed, DC, PhD
Mentor: Joel Pickar, DC, PhD

This study is directed toward understanding the consequences of restricted or excessive spinal joint mobility on neural responses to spinal manipulation for back pain.

Publications
Reed WR, Pickar JG, Long CR. Effect of Lumbar Stiffness Changes Due to Single Facet Joint Dysfunction on Muscle Spindle Responsiveness to Ramp and Hold Vertebral Movement. 2014 J Canadian Chiropractic Association (accepted)

Reed WR, Long CR, Pickar JG. Effects of Unilateral Facet Fixation and Facetectomy on Muscle Spindle Responsiveness during Simulated Spinal Manipulation in an Animal Model. J Manipulative Physiol Ther 2013;36(9):585-594.

Distance Education OnLine Intervention for Evidence Based Practice Literacy (DELIVER)

Funding source: NIH/NCCAM
Grant number: 1-R21-AT007547
Funding period: 9/2012 – 8/2014
Principal Investigator: Michael Schneider, DC, PhD, University of Pittsburgh
Co-investigator: Cynthia Long, PhD

This project will test on online intervention for increasing doctors of chiropractic attitudes, knowledge and skills regarding evidence-based practice.

Completed Grants and Projects of Note

Co-Management of Older Adults with Low Back Pain by Medical Physicians and Doctors of Chiropractic (COCOA)

Funding source: HRSA
Grant number: R18-HP-15126
Award amount: $1,270,911
Funding period: 9/2009 – 8/2013
Principal investigator: Christine Goertz, DC, PhD
Collaborators: Andrew Andresen, MD; Mark Jones, PharmD; Maria Hondras, DC, MPH; Lisa Killinger, DC; Cynthia Long, PhD; Kevin Lyons, PhD; Paul Mulhausen, MD; Robert Wallace, MD; Robert Vining, DC; Fredric Wollinsky, PhD
Project Manager: Stacie Salsbury, RN, PhD

The long term goal is to enhance human health by improving quality of care through the use of a comprehensive, feasible accessible, effective, team-based multi-disciplinary approach to health care delivery for sub-acute and chronic low back pain in older adults. This project was conducted in collaboration with Genesis Health System, Thomas Jefferson University and the University of Iowa.

Publications
Lyons KJ, Salsbury SA, Hondras MA, Jones ME, Andresen AA, Goertz CM. Perspectives of Older Adults on Co-Management of Low Back Pain by Doctors of Chiropractic and Family Medicine Physicians: A Focus Group Study. BMC Complem Altern M 2013;13:225.

Goertz CM, Salsbury SA, Vining RD, Long CR, Andresen AA, Jones ME, Lyons KJ, Hondras MA, Killinger LZ, Wolinsky FD, Wallace RB. Collaborative Care for Older Adults with Low Back Pain by Family Medicine Physicians and Doctors of Chiropractic (COCOA): Study Protocol for a Randomized Controlled Trial. Trials 2013:14:18.

Weigel PAM, Hockenberry JM, Bentler SE, Kaskie B, Wolinsky FD. Chiropractic Episodes and the Co-occurrence of Chiropractic and Health Services use Among Older Medicare Beneficiaries. J Manipulative Physiol Ther 2012;35(3):168-175.

Goertz C, Salsbury Lyons S, Andresen A, Hondras M, Jones M, Zaynab Killinger L, Long C, Lyons K, Mulhausen P, Vining R. Collaborative Care of Older Adults (COCOA), Palmer College of Chiropractic. J Allied Health 2010;39(3)Pt.2:e135-e136.

Effect of Spinal Manipulation on Thalamic Mechanical Response Threshold

Funding source: Australian Spinal Research Foundation
Grant number: LG2010-11
Award amount: $20,000
Funding period: 6/2011 – 5/2013
Principal Investigator: William Reed, DC, PhD
Key technical support: Randy Sozio, BS, LATG

Manual therapy has been shown to provide a hypoalgesic effect as measured clinically by reduced pressure pain thresholds in both symptomatic and asymptomatic subjects. The objective of this animal study is to determine the effects of simulated spinal manipulation on thalamic mechanical response thresholds using electrophysiological techniques.

Publications
Reed WR, Sozio RS, Pickar JG, Onifer SM. Effects of Spinal Manipulation Thrust Duration on Trunk Mechanical Thresholds of Nociceptive Specific Lateral Thalamic Neurons. 2013 J Manipulative Physiol Ther (in-review)

Developmental Center to Study Mechanisms and Effects of Chiropractic Manipulation (DCRC II)

Funding source: NIH/NCCAM
Grant number: 1-U19-AT004137
Award amount: $3,890,368
Funding period: 7/2007 - 9/2012
Principal investigator: Joel Pickar, DC, PhD

The long range goal of this study is to explore and understand the clinical role of spinal manipulation and the physiological and biomechanical mechanisms of spinal manipulation loads. All three projects under this grant have been completed in collaboration with University of Alberta, SUNY, Stony Brook, University of Toledo and the University of Iowa.

DCRC II: Project 1: Neural & Biomechanical Responses to Mechanical Features of Spinal Manipulation

Co-leaders: Joel Pickar, DC, PhD and Greg Kawchuk, DC, PhD
Co-investigators: Cynthia Long, PhD; William Reed, DC, PhD

Publications
Reed WR, Long CR, Kawchuk GN, Pickar JG. Neural Responses to the Mechanical Parameters of a Hight Velocity, Low Amplitude Spinal Manipulation: Effect of Perload Parameters. 2013 JMPT (in-press)

Edgecombe TL, Kawchuk GN, Long CR, Pickar JG. The Effect of Application Site of Spinal Manipulative Therapy on Spinal Stiffness. The Spinal Journal 2013 (in-press)

Reed WR, Cao D-Y, Long CR, Kawchuk GN, Pickar JG. Relationship between Physical Characteristics of Spinal Manipulation and Neural Response in an Animal Model: Effect of Thrust Amplitude, Duration, Rate and Type of Linear Thrust Control. Evid-Based Compl Alt 2013: Article 492039.

Cao DY, Reed WR, Long CR, Kawchuk GN, Pickar JG. Effects of Thrust Amplitude and Duration of High-velocity, Low-amplitude Spinal Manipulation on Lumbar Muscle Spindle Responses to Vertebral Position and Movement. J Manipulative Physiol Ther 2013;36(2):68-77.

Vaillant M, Edgecombe T, Long C, Pickar JG, Kawchuk GN. The Effect of Duration and Amplitude of Spinal Manipulative Therapy on the Spinal Stiffness in a Feline Model. Manual Ther 2012;17(6):557-583.

Reed WR, Cao D-Y, Long CR, Kawchuk GN, Pickar JG. Neural Responses to the Mechanical Characteristics of a High Velocity, Low Amplitude Spinal Manipulation: Effect of Varying Thrust Amplitude and Thrust Duration. Spine J 2012 (submitted, rejected)

Vaillant M, Pickar JG, Kawchuk GN. Performance and Reliability of a Variable Rate, Force/Displacement Application Systems. J Manipulative Physiol Ther 2010;33(8):585-593.

DCRC II: Project 2: Vertebral Displacements & Ligament Strains During Simulated Spinal Manipulation

Co-leaders: Ram Gudavalli, PhD and Yi-Xian Qin, PhD
Co-investigators: Ting Xia, PhD; Vijay K. Goel, PhD

DCRC II: Project 3: Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients (D2P3)

Co-leaders: Christine Goertz, DC, PhD and David Wilder, PhD
Co-investigators: Cynthia Long, PhD; Ram Gudavalli, PhD; James DeVocht, DC, PhD; Robert Vining, DC; Ting Xia, PhD

Publications
Vining R, Potocki E, McLean I, Seidman M, Morgenthal AP, Boysen J, Goertz C. Prevalence of Radiographic Findings in Individuals with Chronic Low Back Pain Screened for a Randomized Controlled Trial: Secondary Analysis and Clinical Implications. 2013 JMPT (accepted)

Wilder DG, Vining RD, Pohlman KA, Meeker WC, Xia T, DeVocht JW, Gudavalli RM, Long CR, Owens EF, Goertz CM. Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients: Study Protocol for Randomized Controlled Trial. Trials 2011 June 28;12:161.

DCRC II: Data Management and Biostatistics Core

Leader: Cynthia Long, PhD

Chiropractic for Hypertension in Patients (CHiP)

Funding source: Palmer College of Chiropractic and NIH/NCCAM
Study period: 11/2010 – 3/2012
Principal investigator: Christine Goertz, DC, PhD
Co-investigators: Cynthia Long, PhD; Robert Vining, DC
Consultant: Geravasio Lamas, MD, Mount Sinai Medical Center, Heart Institute
Project Managers: Katherine Pohlman, DC, MS, CCRP; Stacie Salsbury, RN, PhD

This pilot study evaluated the efficacy of toggle recoil spinal manipulation for lowering systolic or diastolic blood pressure in stage one and pre-hypertensive patients.

The Efficacy of Manual and Manipulative Therapy for Low Back Pain in Military Active Duty Personnel: A Feasibility Study

Grant number: 1-EA-0000055
Study period: 6/2007-6/2009
Principal investigator: Christine Goertz, DC, PhD
Co-investigators:Cynthia Long, PhD; Maria Hondras, DC, MPH; Richard Petri, MD; Roxana Delgado, MS; Dana Lawrence, DC, MMedEd, MA; Edward Owens, MS, DC; William Meeker, DC, MPH

The goal of this feasibility project is to explore the use of manipulative therapy in restoring peak performance in military personnel with low back pain in operational environments.

Publications
Goertz CM, Long CR, Hondras MA, Petri R, Delgado R, Lawrence DJ, Owens EF, Meeker WC. Adding Chiropractic Manipulative Therapy to Standard Medical Care for Patients with Acute Low Back Pain: Results of a Pragmatic Randomizeed Comparative Effectiveness Study. Spine 2013;38(8):627-634.

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