The Network is a collaborative effort between the Palmer Center for Chiropractic Research (PCCR), Yale University Section of Biomedical Informatics and Data Science, and the Osher Center for Integrative Health (jointly based at Harvard Medical School and Brigham and Women’s Hospital).
Co-Directors: Cynthia Long, Ph.D.; Anthony Lisi, D.C.; Peter Wayne, Ph.D.
Steering Committee Members: Matt Kowalski, D.C.; Robert Vining, D.C., D.H.Sc.
Program Manager: Zachary Almquist, M.A.
Funding Source: Palmer College Foundation
Projects
IMPACT Study Project Description
Title: Integrative Migraine Pain Alleviation through Chiropractic Therapy: The IMPACT Study
Funding Source: Osher Center for Integrative Medicine, NCMIC, Palmer College Foundation
Principle Investigators: Peter Wayne, Ph.D., Carolyn Bernstein, M.D.
Co-Investigators: Cynthia Long, Ph.D., Robert Vining, D.C., DHSc
Performance Period: 2017-2021
Site Location: The Osher Center for Integrative Medicine
Description: This pilot-controlled trial was conducted at the Osher Clinical Center in preparation for a larger trial.
Status: Completed
Publications:
Rist PM, Bernstein C, Kowalski M, Osypiuk K, Connor JP, Vining R, Long CR, Macklin EA, Wayne PM. Multimodal chiropractic care for migraine: a pilot randomized controlled trial. Cephalalgia 2021;41(3):318-328.
Wayne PM, Bernstein C, Kowalski M, Connor JP, Osypiuk K, Long CR, Vining R, Macklin E, Rist PM. The integrative migraine pain alleviation through chiropractic therapy (IMPACT) trial: study rationale, design and intervention validation. Contemp Clin Trials Commun 2020;17
Rist PM, Hernandez A, Bernstein C, Kowalski M, Osypiuk K, Vining R, Long CR, Goertz C, Song R, Wayne PM. The impact of spinal manipulation on migraine pain and disability: a systematic review and meta-analysis. Headache 2019;59(4):532-542.
UnitedHealthcare Neck Pain Project
Principal Investigator: Anthony Lisi, D.C.
Steering Committee Members: Scott Haldeman, D.C., M.D., Ph.D.; Jason Sico, M.D., M.H.S.; Peter Way, Ph.D.
Collaborators: Yale University Section of Biomedical Informatics and Data Science, UnitedHealthcare and UC Davis
Description: To replicate the Optum Low Back Pain Study for chiropractic patients with neck pain.
Presentations:
Lisi A, Bastian L, Brandt C, Coleman B, Goulet J. The impact of chiropractic care on opioid prescription fills in Veterans Health Administration patients receiving care for neck pain conditions. International Congress on Integrative Medicine and Health, April 9-13, 2024.
Coleman B, Corcoran K, Lisi A, Finch D, Luther S, Brandt C. Iterative development of a natural language processing model to identify patient reported outcome measure documentation in VA chiropractic care. International Congress on Integrative Medicine and Health, April 9-13, 2024.
Romano P, Ray M, Fang SY, Elton D, Haldeman S, Wayne P, Fenton J, Padilla K, Lisi A. First-seen provider and pharmacotherapy patterns among patients with new-onset neck pain. Integrative Medicine & Health Symposium, February 28-March 2, 2023, Chicago, IL.
Lisi AJ, Bastian LA, Brandt CA, Coleman BC, King JT, Goelet JL. The impact of chiropractic care on opioid prescriptions in Veterans Health Administration patients receiving care for low back conditions. North American Spine Society Annual Meeting, October 18-21, 2023, Los Angeles, CA.
Publications:
Fenton JJ, Fang SY, Ray M, Kennedy J, Padilla K, Amundson R, Elton D, Haldeman S, Lisi A, Sico J, Wayne P, Romano PS. Longitudinal care patterns and utilization among patients with new-onset neck pain by initial provider specialty. Spine (Phila Pa 1976). 2023 Oct 15;48(20):1409-1418.
Coleman BC, Lisi Aj, Abel EA, Runels T, Goulet JL. Association between early nonpharmacological managements and follow-up for low back pain in the Veteran Health Administration. N AM Spin Soc J. 2023 Jun 1:14:10023.
Coleman BC, Finch D, Wang R, Luther SL, Heapy A, Brandt C, Lisi AJ. Extracting pain care quality indicators from U.S. Veterans Health Administration chiropractic care using natural language processing. App Clin Inform. 2023;14(03):600-608.
Integrating Chiropractic Care & Mind-Body Training for the Treatment of Non-specific Chronic Neck Pain
Principal Investigator: Peter Way, Ph.D.
Site: Osher for Integrative Medicine
Study Team: Pamela Rist, Sc.D.; Matt Kowalski, D.C.; Wren Burton, D.C.
Description: Pilot study of nurses with chronic neck pain receiving chiropractic, Tai Chi and other mind-body therapies.
Presentations:
Burton W, Kowalski M, Litrownik D, Wayne P. Integrating chiropractic care and Tai Chi training for the treatment of chronic nonspecific neck pain in nurses. ACC-RAC Conference, March 23-25, 2023, New Orleans, LA.
Burton W, Litrownik D, Kowalski M, Wayne P. Integrating chiropractic care and Tai Chi training for the treatment of chronic nonspecific neck pain in nurses. Integrative Medicine and Health Symposium, February 28 – March 2, 2023, Chicago, IL.
Burton W, Kowalski M, Litrownik D, Wayne P. Integrating chiropractic care and Tai Chi training for the treatment of chronic nonspecific neck pain in nurses. ACC-RAC Conference, March 23-25, 2023, New Orleans, LA.
Publications:
Burton W, Wayne PM, Litrownik D, Long CR, Vining R, Rist P, Kilgore K, Lisi A, Kowalski. Integrating chiropractic care and Tai Chi training for the treatment of chronic non-specific neck pain in nurses: A single-arm mixed-methods pilot trial. J Integr Complement Med. 2024;30(12):1189-1199.
Longitudinal Cohort Assessing Healthcare Service use for Spine-Related Disorders in the VA
Principle Investigator: Anthony Lisi, D.C.
Site: Yale University Section of Biomedical Informatics and Data Science
Description: Evaluate differences in healthcare use and outcomes in administrative data among a large cohort of U.S. veterans receiving care in Veterans Health Administration facilities.
Presentations:
Coleman B, Corcoran K, Lisi A, Finch D, Luther S, Brandt C. Iterative development of a natural language processing model to identify patient reported outcome measure documentation in VA chiropractic care. International Congress on Integrative Medicine & Health. April 11-13, 2024, Cleveland, OH.
Coleman B, Ma P, Lisi A, Goulet J, Zeng Q. Phenotypes of early low back pain health service use by veterans receiving Veterans Health Administration care. International Congress on Integrative Medicine & Health. April 11-13, 2024, Cleveland, OH.
Corcoran K, Coleman B, Zhao C, Bastian L, Brandt C, Lisi A. The impact of Veterans Health Administration chiropractic care on the use of prescription pain medication for veterans with low back pain. International Congress on Integrative Medicine & Health. April 11-13, 2024, Cleveland, OH.
Lisi A, Bastian L, Brandt C, Coleman B, Goulet J. The impact of chiropractic care on opioid prescription fills in Veteran Health Administration patients receiving care for neck pain conditions. International Congress on Integrative Medicine & Health. April 11-13, 2024, Cleveland, OH.
Coleman B, Corcoran K, Lisi A, Brandt C. Identifying documentation of patient reported outcome measures in Veterans Health Administration chiropractic care using rule-based natural language processing. ACC-RAC Conference, March 21-23, 2024, San Diego, CA.
Lisi AJ, Bastian LA, Brandt CA, Coleman BC, King JT, Goulet JL. The impact of chiropractic care on opioid prescriptions in Veterans Health Administration patients receiving care for low back conditions. North American Spine Society Annual Meeting. October 19-21, 2023, Los Angeles, CA.
Chart Review of Characteristics of Veterans Health Administration Chiropractic Care
Principal Investigator: Anthony Lisi, D.C.
Site: Yale University Section of Biomedical Informatics and Data Science
Description: Investigate elements of quality care, such as how visit dosage of exercise, adjustments, and patient education during care.
Presentations:
Schut SM, Graham SE, Sites AR, Coleman BC, Lisi AJ. Describing congruence between CPT codes and medical record text in Veterans health Administration chiropractic notes. ACC-RAC Conference, March 21-24, 2024, San Diego, CA.
Bensel V, Corcoran K, Lisi A. Forecasting the use of chiropractic services within the Veterans Health Administration. ACC-RAC Conference, March 21-23, 2024, San Diego, CA.
Lisi A, Graham S, Skanderson M, Best R, Seng E, Sico J. Assessing the use of Veterans Health Administration chiropractic care by patients with headache disorders. Integrative Medicine and Health Symposium, February 28–March 2, 2023, Chicago, IL.
Graham S, Sites A, Zhao X, Lisi A. Assessing referral patterns to on-station chiropractic clinics within the Veterans Health Administration. ACC-RAC Conference, March 23-25, 2023, New Orleans, LA.
Corcoran K, Coleman B, Zhao X, Bastian L, Brandt C, Lisi A. Assessing downstream healthcare utilization for low back pain among chiropractic users versus non-users in the Veterans Health Administration. ACC-RAC Conference, March 23-25, 2023, New Orleans, LA.
Sharma N, Graham S, Sites A, Coleman B, Lisi A. Describing congruence between ICD-10 coding and medical record text in Veterans Health Administration chiropractic notes. ACC-RAC Conference, March 23-25, 2023, New Orleans, LA.
Muller R, Graham S, Sites A, Corcoran K, Lisi A. Assessing quality indicators and guideline-concordance in chiropractic low back pain visits in the Veterans Health Administration. ACC-RAC Conference, March 23-25, 2023, New Orleans, LA.
Publications:
Graham SE, Coleman BC, Zhao C, Lisi AJ. Evaluating the rates of chiropractic use and utilization by patient sex within the United States Veterans Health Administration: A serial cross-sectional analysis. Chiropr Man Therap. 2023 Aug 10;31(1):29.
Administrative Database of Veterans Health Administration Chiropractic Use in Headache Patients
Principal Investigator: Anthony Lisi, D.C.
Co-Investigators: Jason Sico, M.D., M.H.S. (National Director, Head Centers of Excellence Program, VA); Matt Kowalski, D.C.; Cynthia Long, Ph.D.; Robert Vining, D.C., DHSc; Peter Wayne, Ph.D.
Site: Department of Veterans Affairs Headache Center of Excellence, VA CT, Yale University Section of Biomedical Informatics and Data Science
Description: Using administrative data in the Headache Centers to compare patients with headache who receive chiropractic care versus those who do not.
Chiropractic Care for Episodic Migraine
Funding Source: NIH/NCCIH
Performance Period: 12/11/2022-11/30/2025
Award Amount: 112,670 (subaward)
Status: Pending Notice of Grant Award
Principal Investigator: Peter Wayne, PhD; Pamela Rist, ScD; Jason Sico, MD, MHS.
Co-investigators: Anthony Lisi, DC; Cynthia Long, PhD; Robert D Vining DC, DHSc.
Sites: Osher Clinical Center and West Haven, CT VA Hospital.
Description: A 2-site pilot randomized trial of 60 patients (men and women) diagnosed with episodic migraine (R01 multisite feasibility clinical trial).
Presentations:
Wayne P, Bernstein C, Kowalski M, Osypiuk K, Connor J, Vining R, Long C, Maklin E, Rist P. Chiropractic care for migraine: A Pilot randomized clinical trial. International Congress on Integrative Medicine and Health Conference, April 28 – May 1, 2020, Cleveland Ohio.
Combined Chiropractic and Tai Chi for Chronic Non-Specific Neck Pain (CHRONECK)
Funding Source: NIH/NCCIH
Performance Period: 09/12/2022 – 05/30/2025
Principal Investigator: Peter Wayne, Ph.D.
PCCR Consultants: Cynthia Long, Ph.D; Robert Vining, D.C., DHSc.
Sites: Osher Center for Integrative Health at Harvard/BWH; Chiropractic and Tai Chi centers in Boston, MA.
Description: A 3-armed mixed methods pilot randomized trial of 48 patients with chronic pain with care from community-based Tai Chi instructors and chiropractors (R34 clinical trial planning grant application).
Publications
Wayne PM, Vining R, Long CR, Burton W, Litrownik D, Guzman J, Kilgore K, Hagan TJ, Lauche R, Rist PM, Kowalski MH. Combined chiropractic care and Tai Chi for chronic neck pain: A protocol for a pilot randomized trial. Contemp Clin Trials Commun. 2025;45:101482
Chiropractic Care for Fall Prevention
Principal Investigator: Peter Wayne, Ph.D.
Lead Authors: Wren Burton, DC; Weronika Gabowska, MPH
Site: Osher Center for Integrative Health
PCCR co-authors: Cynthia Long, PhD; Robert Vining, DC, DHSc
Publication:
Grabowska W, Burton W, Kowalksi MH, Vining R, Long CR, Lisi A, Hausdorff JM, Manor B, Munoz-Vergara D, Wayne PM. A systematic review of chiropractic care for fall prevention: rationale, state of the evidence, and recommendations for future research. BMC Musculoskelet. Disord. 2022;23:844.
Presentations:
Burton W, Grabowska W, Kowalski M, Long C, Bining R, Lisia, Munoz-Vergara D, Wayne P. Chiropractic care for fall prevention in our aging society: Rationale, state of the evidence, and a research agenda. ACC-RAC Conference, July 24-26, 2022, San Diego, CA.
Integration of Systematic Gait Monitoring into Chiropractic Care in an Academic Hospital Clinic Setting
Principal Investigation: Peter Wayne, Ph.D.
Co-Investigator: Wren Burton, D.C., M.P.H.
Site: Osher Center for Integrative Health at Harvard and Brigham’s Women’s Hospital.
Description: Developed protocols for gait data capturing, collected longitudinal gait health outcomes, and developed patient-centered reports of both gait and clinical health.
Publication:
Burton W, Ma Y, Manor B, Hausdorff JM, Kowalski MH, Bain PA, Wayne PM. The impact of neck pain on gait health: A systematic review and meta-analysis. BMC Musculoskelet Disord. 2023;24:618.
Presentation:
Burton W, Kowalski M, Long C, McCarey J, Vining R, Hausdorff J, Manor B, Rist P, Wayne P. Gait health in individuals with chronic nonspecific neck pain. International Congress on Integrative Medicine and Health, April 9-13, 2024.
